Seventh Generation’s Free & Clear Liquid Laundry Detergent is the best pick for a household with sensitive skin. The manufacturer states the formula was tested for skin irritation and sensitization, leaves out dyes, fragrance, and optical brighteners, and publishes its full ingredient list on its own page, with two certification claims behind it. The other two detergents here make sensitive-skin claims of their own, and one of them, Arm & Hammer, states more about its testing than either pick above it. What decides the order is how much each formula leaves out and how much each brand discloses, because no regulator defines what “sensitive skin” or “hypoallergenic” has to mean.

The picks at a glance
ProductFormatSizeFragranceCertifications claimed
Seventh Generation Free & Clear Liquid Laundry DetergentSeventh Generationliquid100 fl oz66 loadsFragrance-freeSafer Choice, BioPreferred
ECOS Free & Clear Liquid Laundry DetergentECOSliquid100 fl oz100 loadsUnscentedSafer Choice, NEA Seal of Acceptance
Arm & Hammer Sensitive Skin Free & Clear Liquid Laundry DetergentArm & Hammerliquid50 loads50 loadsFragrance-freeNot yet checked
Every value is from the manufacturer's own site and is sourced and dated beneath each pick below. "Not published" means the brand's own page lists no ingredients; "None claimed" means it names no certification; "Not yet checked" means we haven't read it. A certification is the brand's claim unless its row says otherwise.

Why sensitive skin changes the math

Washed fabric sits against skin all day, so the question for a sensitive-skin household is what’s in the formula that fabric was washed in. The three manufacturers here answer it the same way. Each one leaves out added fragrance and dyes, and each one says so on its product page. Where they differ is everything after that: optical brighteners, preservatives, and what kind of testing sits behind the claim.

Two words on the labels need care. “Fragrance-free” and “unscented” are not the same claim, and Fragrance-Free vs. Unscented, and Why the Difference Matters explains the gap. “Hypoallergenic” has no regulatory definition at all. When a brand uses it, the useful question is what it did to earn the word, and this guide quotes each brand’s own answer.

Only one of the three disclosed ingredient lists here, Seventh Generation’s, includes enzymes. What the Enzymes in Laundry Detergent Actually Do covers what they are and why a formula carries them. If you’re working out how much a year you’ll actually go through, our laundry detergent calculator has that math.

Our pick: Seventh Generation Free & Clear Liquid Laundry Detergent

Seventh Generation

Seventh Generation Free & Clear Liquid Laundry Detergent

liquid · 100 fl oz

Seventh Generation states the formula has been “tested for skin irritation and sensitization” and contains no added dyes or fragrances. It is also the only pick here that names optical brighteners as left out. Neither of the other two makes that statement, and one of them lists a brightener in its formula.

Ingredients

IngredientWhat it does
Laureth-6Plant-derived surfactant that lifts soil off fabric
Sodium Lauryl SulfatePlant-derived surfactant that cleans and produces suds
Sodium CitratePlant-derived water softener that helps surfactants work better
Protease enzyme blendBreaks down protein-based stains
Amylase enzyme blendBreaks down starch-based stains
Mannanase enzyme blendBreaks down plant-gum-based food stains
BenzisothiazolinonePreservative
MethylisothiazolinonePreservative

Sourceseventhgeneration.comChecked Sep 17, 2026

Certifications

Compatibility

HE compatible
"Great results in HE and standard machines," per manufacturer
Cold water
"Works in all water temperatures," per manufacturer
Septic
"Septic Safe," per manufacturer

Sourceseventhgeneration.comChecked Sep 17, 2026

Read the ingredient list before you decide. It includes two preservatives, benzisothiazolinone and methylisothiazolinone. The manufacturer’s irritation testing covers the formula as sold, preservatives included. If you already know you react to a specific preservative, the list is where to check.

Runner-up: ECOS Free & Clear Liquid Laundry Detergent

ECOS

ECOS Free & Clear Liquid Laundry Detergent

liquid · 100 fl oz

ECOS describes the formula as hypoallergenic and states it was “tested to verify it is unlikely to irritate skin allergies.” It’s made without added dyes or fragrances, and the manufacturer claims Safer Choice certification. The National Eczema Association’s own product directory also lists it, as ECOS Hypoallergenic Laundry Detergent, Free & Clear. The disclosed ingredient list is the shortest of the three, at five entries.

Ingredients

IngredientWhat it does
Cocamidopropyl BetainePlant-derived (coconut) surfactant
Sodium Coco-SulfatePlant-derived (coconut) surfactant
Cocamidopropylamine OxidePlant-derived (coconut) surfactant
PhenoxyethanolPreservative
MethylisothiazolinonePreservative

Sourceecos.comChecked Sep 17, 2026

Certifications

Compatibility

HE compatible
Manufacturer dosing instructions specify "For High Efficiency loads, pour one ounce into the dispenser or washer drum"
Cold water
"Works beautifully in all water temperatures," per manufacturer
Septic
"Safe for use with septic systems," per manufacturer
Greywater
"Safe for use with...greywater tanks," per manufacturer

Sourceecos.comChecked Sep 17, 2026

It comes second on two counts. The page makes no statement about optical brighteners either way, where Seventh Generation names them as excluded. And its own page claims one certification to the top pick’s two. Like the top pick, it lists a preservative, methylisothiazolinone, alongside phenoxyethanol.

Also consider: Arm & Hammer Sensitive Skin Free & Clear

Arm & Hammer

Arm & Hammer Sensitive Skin Free & Clear Liquid Laundry Detergent

liquid · 50 loads

Arm & Hammer makes the most specific sensitive-skin claims of any product here. The manufacturer describes the formula as dermatologist tested and hypoallergenic, states it “passed four different clinical tests,” and states it earned a 100% rating from SkinSAFE, a program the manufacturer says was developed with the Mayo Clinic. It is also the only pick here that states it contains no preservatives.

Compatibility

HE compatible
"Designed to work in both standard machines and today's energy conscious High Efficiency (HE) models," per manufacturer
Cold water
"Ideal for cold water laundry loads" and "works in all machines & all temperatures," per manufacturer
Septic
Manufacturer's FAQ on the product page states that the cleaning agents in its liquid detergents "are biodegradable and safe for septic systems"

Sourcearmandhammer.comChecked Sep 28, 2026

Ingredients

IngredientWhat it does
WaterSolvent
C10-16 alketh (ethoxylated alcohols)Surfactant that lifts soil off fabric
Sodium laureth sulfateSurfactant that lifts soil off fabric
Sodium carbonateBuilder that softens wash water so surfactants work better
Sodium C10-16 alkylbenzenesulfonateSurfactant that lifts soil off fabric
Acrylic acid homopolymerDispersing agent that keeps loosened soil from resettling
Sodium bicarbonatepH adjuster
Pentasodium DTPAChelating agent that binds hard-water minerals
Disodium distyrylbiphenyl disulfonateOptical brightener
Sodium hydroxidepH adjuster
Nitrilotriacetic acidNon-functional constituent, per the disclosure form

Sourcechurchdwight.comChecked Sep 28, 2026

Not yet checked

We haven't read Arm & Hammer's page for Arm & Hammer Sensitive Skin Free & Clear Liquid Laundry Detergent's certifications yet.

Two things keep it out of the top two. Its disclosed ingredient list includes an optical brightener, disodium distyrylbiphenyl disulfonate, which the two picks above either exclude or don’t mention. And SkinSAFE is not one of the certification programs Runlow tracks, so its rating renders here as a manufacturer statement rather than as a certification. If a preservative-free formula matters more to you than a brightener-free one, this is the pick that gives you that trade.

Not checked yet: Tide, Gain, and Persil

Tide

Tide HE Original Liquid Detergent

liquid · 138 fl oz

Gain

Gain Original Liquid Detergent

liquid · 154 fl oz

Persil

Persil Original Liquid Detergent

liquid · 84 fl oz

Our records for these three carry no sensitive-skin guidance and no ingredient list, and this guide says so rather than treating an unchecked record as a product with nothing to offer. When those records are filled in, this guide will be updated to reflect what’s found.

How we researched this

Every fact in this guide comes from each brand’s own website: product pages, the manufacturer’s own ingredient disclosure pages, and the sensitive-skin statements each brand makes there. Nothing was retrieved through SmartLabel or any third-party ingredient database. One listing is confirmed in the issuer’s own directory: the National Eczema Association lists ECOS’s detergent. Every other certification is a manufacturer claim, since the live directories at EPA and USDA could not be searched by exact product with the tools available. Each certification name links to that issuer’s directory so you can run that check yourself. Testing claims are quoted from the manufacturer and are the manufacturer’s own. Runlow has not tested any of these products. Where a record hasn’t been researched for an attribute, the page shows that as a written gap rather than a blank. No prices are shown. Every retailer link goes to a search results page for the exact product, not a specific listing, so it stays accurate regardless of what’s currently in stock.

Frequently asked questions

Is "hypoallergenic" a regulated term?
No. Each manufacturer decides what it means by the word and how it tested for it. This guide quotes what each brand actually states about its testing, dermatologist review, or third-party rating, and links to the page where that statement appears, so you can weigh the claim yourself.
Do "free and clear" detergents leave out preservatives?
Not always. Two of the three picks here list a preservative in their disclosed ingredients, and one states it contains none. A free-and-clear name usually means no added dyes or fragrance. Anything beyond that is in the ingredient list, which is why this guide renders each one in full.
What about Tide, Gain, and Persil?
Our records for those three carry no sensitive-skin guidance and no ingredient list, so this guide doesn't rank them. That is a gap in what we've gathered, not a verdict on the products. When those records are filled in, this guide will be updated.